Asymptomatic Atherosclerosis: Pathophysiology, Detection and by Morteza Naghavi (auth.), Morteza Naghavi (eds.) PDF

By Morteza Naghavi (auth.), Morteza Naghavi (eds.)

ISBN-10: 1603271783

ISBN-13: 9781603271783

Despite contemporary advances within the analysis and therapy of symptomatic atherosclerosis, to be had conventional screening tools for early detection and therapy of asymptomatic coronary artery illness are grossly inadequate and fail to spot nearly all of sufferers ahead of the onset of a life-threatening occasion. In Asymptomatic Atherosclerosis: Pathophysiology, Detection and therapy, Dr. Morteza Naghavi and top professionals from the Society for middle assault Prevention and Eradication (SHAPE) current a brand new paradigm for the screening and first prevention of asymptomatic atherosclerosis.

The textual content specializes in exact, but underutilized, measures of subclinical atherosclerosis, particularly coronary artery calcium scanning and carotid intima-media thickness size. The authors introduce a accomplished method of settling on the susceptible sufferers (asymptomatic members liable to a close to destiny opposed event). extra chapters talk about destiny instructions in the direction of containing the epidemic of atherosclerotic heart problems utilizing cutting edge suggestions equivalent to preemptive interventional cures (bioabsorbable stents) for stabilization of susceptible atherosclerotic plaques, mass unconditional Polypill remedy for population-based threat relief, and eventually vaccination recommendations to avoid the improvement of atherosclerosis.

Up-to-date and authoritative, Asymptomatic Atherosclerosis: Pathophysiology, Detection, and therapy is a must have for any heart specialist or basic care health professional who needs to perform sleek preventive cardiology and deal with the expanding variety of asymptomatic atherosclerotic patients.

• Outlines extra exact measures of chance (coronary artery calcium and carotid intima-media thickness) than conventional probability components (total ldl cholesterol, cholesterol, HDL cholesterol)

• provides new multipronged suggestions to help within the early detection and therapy of excessive chance asymptomatic patients

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Additional info for Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment

Example text

22. Mann J, Davies MJ. Mechanisms of progression in native coronary artery disease: role of healed plaque disruption. Heart. 1999;82:265–268. 23. Burke AP, Farb A, Malcom GT, et al. Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med. 1997;336:1276–1282. 34 Naghavi and Falk 24. Goldstein JA, Demetriou D, Grines CL, et al. Multiple complex coronary plaques in patients with acute myocardial infarction. N Engl J Med. 2000;343:915–922. 25. Nissen SE.

We propose a classification for clinical as well as pathological evaluation of vulnerable plaques. (2) Vulnerable plaques are not the only culprit factors for the development of acute coronary syndromes, myocardial infarction, From: Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment Edited by: M. 1007/978-1-60327-179-0_2 © Springer Science+Business Media, LLC 2010 13 14 Naghavi and Falk and sudden cardiac death. Vulnerable blood (prone to thrombosis) and vulnerable myocardium (prone to fatal arrhythmia) play an important role in the outcome.

Possible intravascular diagnostic techniques [34, 35] include thermography (measurement of plaque temperature) [36, 37], contrast-enhanced (CE) MRI [38, 39], fluorodeoxyglucose positron emission tomography [33, 40], and immunoscintigraphy [41]. It has been shown that optical coherence tomography reflects the macrophage content of the fibrous cap [42]. Noninvasive options include MRI with superparamagnetic iron oxide [35, 36] and gadolinium fluorine compounds [43–45]. A Thin Cap With a Large Lipid Core These plaques have a cap thickness of <100 mm and a lipid core accounting for >40% of the plaque’s total volume [8].

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Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment by Morteza Naghavi (auth.), Morteza Naghavi (eds.)


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